Answers are grounded in this paper and cite their sources.
We demonstrate that ligand-directed tosyl (LDT) chemistry is applicable to off-target identification in live cells. Lapatinib (Lap)-based LDT reagents not only labeled a receptor tyrosine kinase, HER2, target protein, but also the protein disulfide isomerase (PDI) that should be an off-target protein for Lap.
No takes yet. Share an insight, caveat, or question.
Yamaura et al. (2014) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: