Why the study?
Knowledge regarding the dynamic changes and evolutionary pathway of immunodeficiency vaccine-derived poliovirus populations during long-term replication was limited.
The study details the genetic and phenotypic evolution of vaccine-derived poliovirus in a single immunodeficient patient over 10 months, highlighting mechanisms of neurovirulence reversion.
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Prolonged iVDPV shedding in PID may sustain transmission risk; hypothesis-generating for targeted polio surveillance in immunocompromised hosts.
Fan et al. (2022) studied this question.
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