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Highlights mechanistic links in ACS without altering management; leaves open targeted trials on lipoprotein modulation.
A broad range of molecular and cellular interactions contribute to various pathophysiological alterations in haemostasis. Recent studies have shown strong links between lipoproteins and coagulation factors. Findings suggest that lipoproteins play an important role in the fibrinolytic and thrombogenic mechanisms that influence the risks of patients in acute coronary syndromes. We will examine specific aspects of lipoproteins with reference to the effects of hyperlipidaemia on endothelial dysfunction and haemostasis, and its relevance in the patient presenting for revascularization.
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Basile-Borgia et al. (1997) studied this question.
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