Comparative study reveals classification accuracies of 0.81 to 0.84 between low-cost and high-end SERS detectors in chronic disease, indicating feasible portable screening.
The aim of the study is to compare the performance of surface‐enhanced Raman spectroscopy (SERS) analysis of serum using a non‐cooled detector ( EnSpectr R785 ) and a high spectral resolution detector ( Renishaw ) in the task of discrimination between the patients with chronic heart failure and the patients with chronic obstructive pulmonary disease. The SERS‐based solution of the classification problem demonstrates an insignificant relationship between the disease classification accuracy and detector quality (classification accuracy for the high‐resolution setup is 0.84 and for the low‐cost setup is 0.81). In the data recorded on Renishaw setup, the most significant bands are 611, 675, 720, 804, 1187, 1495, and 1847 cm −1 ; for the EnSpectr setup—721, 1051, and 1665 cm −1 . The results have revealed equal discrimination capabilities in the EnSpectr and the Renishaw setups; however, the Renishaw setup has more prospects for identifying the spectral contribution of pathologically associated analytes.
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Bratchenko et al. (2025) studied this question.
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