Key result
Diabetic retinopathy is linked to ~2.3-fold higher risk of incident ischemic stroke in diabetes.
Cohort (n=1,617)
Yes
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BACKGROUND AND PURPOSE: The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS: A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. RESULTS: Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). CONCLUSIONS: Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.
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Cheung et al. (2006) conducted a cohort in Diabetes (n=1,617). Diabetic retinopathy vs. Absence of diabetic retinopathy was evaluated on Incident ischemic stroke (HR 2.34, 95% CI 1.13-4.86). Diabetic retinopathy was independently associated with an increased risk of incident ischemic stroke in persons with diabetes (HR 2.34; 95% CI 1.13-4.86).
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