Analysis of correlations between biomarkers assessed with swept-source OCT and OCT angiography in naïve patients with diabetic macular edema treated with aflibercept: a prospective study

Marcussi Palata Rezende; Fernanda Atoui Faria; Daniel Prado Beraldo; Júlia Polido; Rubens Belfort Neto; Thiago Cabral

doi:10.1186/s40942-025-00777-z

December 17, 2025International Journal of Retina and VitreousOpen Access

Analysis of correlations between biomarkers assessed with swept-source OCT and OCT angiography in naïve patients with diabetic macular edema treated with aflibercept: a prospective study

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Key Points

To prospectively evaluate correlations among retinal and choroidal biomarkers before and after aflibercept therapy in treatment-naïve diabetic macular edema using swept-source OCT and OCT angiography.
Conducted a prospective interventional case series of 28 eyes from 25 treatment-naïve patients with diabetic macular edema.
Administered three monthly intravitreal aflibercept injections and reassessed outcomes at a 4-month follow-up visit.
Measured BCVA, central macular thickness, central choroidal thickness (CCT), vessel density (VD), and avascular area of the superficial and deep plexus (AADP) using SS-OCT and SS-OCTA.
Baseline and posttreatment central choroidal thickness showed a very high positive correlation (r = 0.98; p < 0.001).
Baseline deep capillary avascular area and vessel density strongly correlated with their posttreatment reductions (AADP: r = -0.93, p < 0.001; VD: r = -0.72, p < 0.001).
All 16 evaluated biomarker correlations reached statistical significance, including 2 very high, 1 high, 4 moderate, and 9 low correlations.

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Implication

Prospective study reveals strong correlations between baseline imaging biomarkers and aflibercept response in diabetic macular edema, suggesting predictive value for personalized therapy.

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Rezende et al. (2025) studied this question.

synapsesocial.com/papers/6a72c35b84cc45bb7be02a87 https://doi.org/10.1186/s40942-025-00777-z

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Analysis of correlations between biomarkers assessed with swept-source OCT and OCT angiography in naïve patients with diabetic macular edema treated with aflibercept: a prospective study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Analysis of correlations between biomarkers assessed with swept-source OCT and OCT angiography in naïve patients with diabetic macular edema treated with aflibercept: a prospective study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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