Population
8 Idiopathic pulmonary fibrosis (IPF) lung samples and 7 healthy controls
Comparison
RNA sequencing (RNA-Seq) vs Healthy controls
Design
Preclinical
Authors
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Should not change IPF management; leaves open whether these splicing events drive human pathogenesis.
RNA sequencing reveals substantial differential gene expression and alternative splicing in IPF lung tissue, suggesting these events may be involved in IPF pathogenesis.
Nance et al. (2014) studied this question.