Key result
Lower normal TSH is linked to ~2.4-fold higher odds of Alzheimer disease.
Case-Control (n=469)
OBJECTIVE: To assess a possible relationship between thyroid-stimulating hormone (TSH) levels, vascular risk factors, and Alzheimer disease (AD). METHODS: TSH levels were measured in 178 AD patients (35 confirmed post mortem) and 291 cognitively screened control subjects who were all euthyroid (TSH: 0.5 to 6 mU/L). The risk of AD was determined in participants with lower levels of TSH, several cerebrovascular risk factors, and other potential confounds. RESULTS: AD patients had significantly lower levels of TSH than control subjects. Lowered TSH was associated with a more than twofold increased risk of AD (odds ratio = 2.36, 95% CI = 1.19 to 4.67), independent of other risk factors. CONCLUSION: Lowered TSH within the normal range is a risk factor for AD, independent of several cerebrovascular risk factors and confounding variables.
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Osch et al. (2004) conducted a case-control in Alzheimer disease (n=469). Lower thyroid-stimulating hormone (TSH) levels within the normal range vs. Higher normal TSH levels / cognitively screened control subjects was evaluated on Alzheimer disease (OR 2.36, 95% CI 1.19-4.67). Lowered thyroid-stimulating hormone within the normal range was independently associated with an increased risk of Alzheimer disease (OR 2.36; 95% CI 1.19-4.67).
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