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Background: Disseminated intravascular coagulation (DIC) treatment is essential for the management of placental abruption.Recombinant human soluble thrombomodulin (rhTM) is a novel anticoagulant that has antifibrinolytic and anti-inflammatory properties.Case: A patient with severe DIC induced by placental abruption with fetal death was successfully treated with the early initiation of rhTM and discharged 2 days after delivery without any complications. Conclusion:Early initiation of rhTM blocks further thrombin generation and can inhibit the coagulation cascade of DIC without increasing the risk of bleeding.rhTM also reduces secondary clinical consequences associated with endothelial damage and systemic inflammation because of antifibrinolytic and anti-inflammatory properties.rhTM administration is a promising therapeutic option for the management of DIC associated with placental abruption with fetal death.
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Uno et al. (2018) studied this question.
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