Key result
Cullin-RING ubiquitin ligases drive key physiological and pathological mechanisms underlying cardiovascular disease.
Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed.
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Diaz et al. (2022) conducted a review in Cardiovascular diseases. Cullin-RING ubiquitin ligases (CRLs) was evaluated. Cullin-RING ubiquitin ligases play essential physiological and pathological roles in the ubiquitin-proteasome system during the pathogenesis of cardiovascular diseases.
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