Why the study?
Does tolbutamide and diet reduce mortality compared to diet alone or diet and insulin in patients in the University Group Diabetes Program?
Population
Patients in the University Group Diabetes Program
Comparison
Tolbutamide and diet vs Diet alone or diet and insulin
Design
Other
Authors
Loading...
May increase CV mortality with tolbutamide; supports UGDP but leaves practice change to further trials.
Does tolbutamide and diet reduce mortality compared to diet alone or diet and insulin in patients in the University Group Diabetes Program?
Further statistical analysis supports the original UGDP conclusion that tolbutamide may increase cardiovascular mortality compared to diet alone.
J. Cornfield (1971) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: