Uterine contractions in endometriosis: Effects of operative and danazol treatment

SummaryTo study uterine contractions in proved endometriosis and the effects of operative and danazol treatment, intrauterine pressures at the isthmus and fundus level were recorded 27 times in 17 women with endometriosis and 20 times in 10 healthy women. In endometriosis a pattern of hypercontractility in the form of increased resting pressure was observed both during the luteal phase of the cycle and during menstruation, whereas the frequency of fundal contractions during the luteal phase was decreased. This pattern of uterine contractions was not affected by operative or danazol (600 mg/day) treatment, although these treatments provided symptomatic relief. These data suggest there is uterine hypercontractility in endometriosis, which seems to be of minor importance in causing symptoms.