January 13 Highlight and Commentary

Lange et al. described a new filamin A mutation in a patient with periventricular nodular heterotopia. Their fMRI data indicated that ectopic neurons were functionally required in motor execution tasks. see page 151 Commentary by Renzo Guerrini, MD Heterotopia agglomerates of morphologically normal neurons in an abnormal site is the most common neuronal migration disorder observed in the human brain. Heterotopia can be unilateral or bilateral, diffuse or localized, subependymal or subcortical, or may extend from the subependymal region to the subcortex. Heterotopia can readily be diagnosed with MRI, showing the same …