Antifungal Activity of Caffeine in Combination with Fluconazole against Candida albicans

-1 , respectively. The combination of caffeine with FLU showed stronger antifungal activity against C. albicans PTCC5027. The addition of 12.5mgL -1 caffeine to FLU 10-50 mgL -1 (below MIC90) inhibited the growth of C. albicans PTCC5027 by 99.3%-99.7%, the concentrations at which neither caffeine nor FLU alone affected the growth. Conclusion: It can be concluded that caffeine has antifungal effect on C. albicans and in combination with FLU can enhance the antifungal activity of FLU against C. albicans . The synergism of the combination of caffeine and FLU induces multiple antifungal effects, resulting in the use of lower doses of the FLU. It suggests that this can decrease the side effects of antifungal drugs.