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August 1, 2002Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Mouse Genetic Evidence That Tranilast Reduces Smooth Muscle Cell Hyperplasia via a p21 WAF1 -Dependent Pathway

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Authors

MSMasataka SataVascular Medicine ATAkihiro TakahashiHokkaido University KTKimie TanakaJuntendo University

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Implication

Tranilast suppresses VSMC hyperplasia via p21 in mice; leaves open its mechanism and efficacy for restenosis in humans.

Key Points

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Cite This Study

Sata et al. (2002) studied this question.

synapsesocial.com/papers/6a72df8bd8e6791e25543d22 https://doi.org/10.1161/01.atv.0000026614.72957.e7

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Histopathology of In-Stent Restenosis in Patients With Peripheral Artery Disease1997 · 267 citations
2Principles for Human Gene Therapy Studies2000 · 65 citations
3Expression of Cyclin-Dependent Kinase Inhibitors in Vascular Disease1998 · 253 citations
4Tranilast Inhibits Vascular Smooth Muscle Cell Growth and Intimal Hyperplasia by Induction of p21waf1/cip1/sdi1and p531999 · 67 citations
5DNA replication and smooth muscle cell hypertrophy1999 · 6 citations