Why the study?
Do beta blockers improve left ventricular function in trauma patients with prolonged sinus tachycardia?
Do beta blockers improve left ventricular function in trauma patients with prolonged sinus tachycardia?
Prolonged sinus tachycardia in severe trauma patients can induce cardiomyopathy that is reversible with beta-blocker therapy.
May support beta blockers for reversible LV dysfunction in trauma tachycardia; hypothesis-generating, needs prospective validation.
Tachycardia induced cardiomyopathy is a potentially lethal cause of heart failure generally because of atrial tachycardia and less frequently ventricular tachycardia. We present two cases of Marines with severe traumatic blast injuries secondary to improvised explosive device attacks whose hospital courses included amputation, massive blood transfusions, and multiple surgeries. Both patients had prolonged sinus tachycardia averaging >110 beats per minute and developed depressed left ventricular function, which recovered when treated with β blockers. Sinus tachycardia is often considered a physiological response to stress, and the purpose of this manuscript is to describe the cardiac injury apparently related to a prolonged stress response. In addition, the literature does not clearly recommend controlling heart rates in trauma patients with persistent sinus tachycardia, but it is a therapeutic option that should be considered by providers.
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Kavanaugh et al. (2014) studied this question.
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