BACKGROUND: The study intends to analyze influences of different anesthesia and analgesia on cellular immune and cognitive functions of patients undergoing thoracotomy for esophageal cancer (EsC). METHODS: Patients undergoing thoracotomy for EsC were divided into four groups: Group A (received general anesthesia [GA]) and postoperative intravenous analgesia); B (received GA and postoperative epidural analgesia); C (received GA combined with thoracic epidural anesthesia [TEA]) and postoperative intravenous analgesia); D (received GA combined with TEA and postoperative epidural analgesia). The T-lymphocyte subsets were determined at 30 min before anesthesia induction (T<inf>0</inf>), 2 h after skin incision (T<inf>1</inf>), and at 4 h (T<inf>2</inf>), 24 h (T<inf>3</inf>), and 48 h (T<inf>4</inf>) after operation. Besides, visual analogue scale (VAS) and mini-mental state examination (MMSE) were assessed. RESULTS: from T<inf>2</inf> to T<inf>4</inf> VAS scores were lower and MMSE scores were higher in groups B, C, and D than in group A, and group D had relatively lower VAS and higher MMSE scores as compared to group B. CONCLUSIONS: The intraoperative general anesthesia combined with thoracic epidural anesthesia and postoperative epidural analgesia may reduce adverse effect on cellular immune and cognitive functions of patients undergoing thoracotomy for EsC.
No takes yet. Share an insight, caveat, or question.
Zhu et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: