Ten new fluorine-containing 1-thiocarbamoyl-3,5-diphenyl-2-pyrazolines 4a-j have been synthesized in 80-85% yield by a microwave-promoted solvent-free condensation of 2,4dichloro-5-fluoro chalcones 3a-j with thiosemicarbazide over potassium carbonate. The work-up is simple and involves treatment with ice-cold water. A considerable increase in the reaction rate has been observed, with better yields.
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Patel et al. (2004) studied this question.
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