Metabolic Activation of Human Neutrophils by Fluid-Phase and Particle-Bound Ligands

The ability of particle-bound and fluid-phase ligands (IgG, C3b, and ConA) to induce metabolic activation in cytochalasin B-treated human neutrophils was studied. Different activation mechanisms of the neutrophils are proposed, since the activation of cytochalasin B-treated neutrophils is not dependent on whether or not the ligands are particle-bound but not on the nature of ligand per se.