Why the study?
Does dosulepin treatment increase QT dispersion in psychiatric outpatients compared to healthy volunteers?
Does dosulepin treatment increase QT dispersion in psychiatric outpatients compared to healthy volunteers?
Dosulepin treatment is associated with significantly increased QT dispersion, which correlates with plasma levels and may serve as a simple marker of its cardiotoxic effect.
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Dosulepin-associated QTd increase may flag cardiotoxicity risk; cross-sectional data leave open predictive value and monitoring thresholds.
Kittnar et al. (2004) studied this question.