The study advocates for incorporating qualitative receptor analysis into a quantitative Widal test for more accurate serological diagnosis of enteric infections.
Warrants caution in Widal interpretation after vaccination; leaves open validation of quantitative receptor methods for enteric diagnosis.
“Normal” agglutinins for B. typhosus and B. paratyphosus B appear to be conclusively of the O type. 2. Such agglutinins appear to be of consistently low titre and are absent in many sera. 3. Normal agglutinins for B. paratyphosus A have not been encountered. 4. O agglutinins are readily produced by inoculation of a T.A.B. vaccine, and may rise to as high titres as those encountered during an enteric infection. 5. It is impossible to fix any limit for residual O agglutinins in inoculated persons. 6. The value of examining for O agglutinins in enteric cases is confirmed. 7. Some fallacies of a purely qualitative method are pointed out, and a plea is made for the inclusion of the principles of qualitative receptor analysis in a quantitative Widal.
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E. S. Horgan (1932) studied this question.
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