What question did this study set out to answer?

To evaluate the estrogenic activities and structure-activity relationships of UV stabilizers used in food contact plastics and a series of hydroxylated benzophenone derivatives.

January 1, 2003Eisei kagakuOpen Access

Estrogenic Activities of UV Stabilizers Used in Food Contact Plastics and Benzophenone Derivatives Tested by the Yeast Two-Hybrid Assay

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Authors

YKYoko KAWAMURAGifu University YOYuko OgawaPhoenixBio (Japan)TNTetsuji NishimuraTeikyo Heisei University

Discussion

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Implication

In vitro screening reveals potent estrogenic activity in benzophenone UV stabilizers used in food contact plastics, highlighting potential endocrine-disrupting risks from packaging materials.

Key Points

To evaluate the estrogenic activities and structure-activity relationships of UV stabilizers used in food contact plastics and a series of hydroxylated benzophenone derivatives.
Screened 11 commercial UV stabilizers commonly used in food contact plastics for estrogenic activity using a yeast two-hybrid assay.
Evaluated benzophenone and 19 hydroxylated derivatives using the yeast two-hybrid assay to establish chemical structure-activity relationships.
Two of 11 UV stabilizers (2-hydroxy-4-methoxybenzophenone and 2,2′-dihydroxy-4-methoxybenzophenone) and 15 of 20 benzophenone derivatives exhibited positive estrogenic activity.
The strongest estrogenic activity was produced by 2,4-dihydroxybenzophenone, 4-hydroxy-4′-chlorobenzophenone, 4-hydroxybenzophenone, and 2,3,4-trihydroxybenzophenone, exceeding the potency of bisphenol A.
Structure-activity analysis revealed that hydroxyl groups at the phenol 4-position conferred the strongest estrogenic activity (4- > 3- >> 2-position), while chlorine substitution enhanced receptor interaction.

Cite This Study

KAWAMURA et al. (2003) studied this question.

synapsesocial.com/papers/6a72f7374d7225e13a154cc2 https://doi.org/10.1248/jhs.49.205

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January 1, 2003Eisei kagakuOpen Access

Estrogenic Activities of UV Stabilizers Used in Food Contact Plastics and Benzophenone Derivatives Tested by the Yeast Two-Hybrid Assay

View Full Paper

Ask AI

Bookmark

Authors

YKYoko KAWAMURAGifu University YOYuko OgawaPhoenixBio (Japan)TNTetsuji NishimuraTeikyo Heisei University

Discussion

Member takes

Implication

In vitro screening reveals potent estrogenic activity in benzophenone UV stabilizers used in food contact plastics, highlighting potential endocrine-disrupting risks from packaging materials.

Key Points

To evaluate the estrogenic activities and structure-activity relationships of UV stabilizers used in food contact plastics and a series of hydroxylated benzophenone derivatives.
Screened 11 commercial UV stabilizers commonly used in food contact plastics for estrogenic activity using a yeast two-hybrid assay.
Evaluated benzophenone and 19 hydroxylated derivatives using the yeast two-hybrid assay to establish chemical structure-activity relationships.
Two of 11 UV stabilizers (2-hydroxy-4-methoxybenzophenone and 2,2′-dihydroxy-4-methoxybenzophenone) and 15 of 20 benzophenone derivatives exhibited positive estrogenic activity.
The strongest estrogenic activity was produced by 2,4-dihydroxybenzophenone, 4-hydroxy-4′-chlorobenzophenone, 4-hydroxybenzophenone, and 2,3,4-trihydroxybenzophenone, exceeding the potency of bisphenol A.
Structure-activity analysis revealed that hydroxyl groups at the phenol 4-position conferred the strongest estrogenic activity (4- > 3- >> 2-position), while chlorine substitution enhanced receptor interaction.

Cite This Study

KAWAMURA et al. (2003) studied this question.

synapsesocial.com/papers/6a72f7374d7225e13a154cc2 https://doi.org/10.1248/jhs.49.205

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