Maternal-fetal transfer of 14C-cyclamate and 14C-cyclohexylamine was studied with the fetus in utero and the amniotic sac intact in rhesus monkeys. Both substances crossed the placenta. With cyclamate, maternal-fetal blood levels of radioactivity were in the approximate ratio of 4:1, suggesting a somewhat limited degree of transmission. By contrast, cyclohexylamine was found to diffuse freely across the primate placenta.
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Pitkin et al. (1969) studied this question.
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