Straightforward Access to a Structurally Diverse Set of Oxacyclic Scaffolds through a Four‐Component Reaction

Just add CH3CN and stir! Four building blocks taken in a multicomponent reaction (MCR, see picture; Tf=trifluoromethanesulfonyl) afford a β-aminoacetal adduct, which can be further diversified by post-condensation reactions. The modular character of this approach, the simplicity of the building blocks used, and the structural diversity attained render this process attractive for combinatorial as well as target- and diversity-oriented synthesis.