Cortisol and Cortisone Acetate in Parenteral Glucocorticoid Therapy?

Intramuscular cortisol and cortisone acetate have been administered to six patients with adrenocortical insufficiency. Plasma cortisol determinations during the following four hours showed a pronounced increase after injection of cortisol, but virtually no increase in five and only a moderate increase in one patient after injection of cortisone acetate. It is therefore recommended not to use cortisone acetate in parenteral glucocorticoid therapy.