Key result
Trimetazidine 80 mg daily added to standard therapy significantly improved heart rate variability parameters (p<0.05) and normalized the myocardial index in patients with stable angina and type 2 diabetes.
Why the study?
Does trimetazidine improve heart rate variability and myocardial index in patients with stable angina and comorbid type 2 diabetes?
RCT (n=110)
Randomized
No
Does trimetazidine improve heart rate variability and myocardial index in patients with stable angina and comorbid type 2 diabetes?
p-value: p=<0.05
Trimetazidine 80 mg daily improves autonomic regulation and heart rate variability in patients with stable angina and comorbid type 2 diabetes.
May support adjunctive trimetazidine for autonomic function in diabetic angina; hypothesis-generating and requires RCT confirmation.
Aim. To assess the dynamics of heart rate variability (HRV) during the therapy with trimetazidine instable angina patients comorbid with diabetes. Material and methods. Totally, 110 stable angina patients studied, of III functional class (FC), comorbid with type 2 diabetes (DM2), that is 53 with diabetic vegetative cardial neuropathy, and other 57 with no diabetes, that is with no vegetative cardial neuropathy, investigated with hardware and software complex. Results. Usage of trimetazidine instable angina patients of III FC, comorbid with DM2, makes it to improve the myocardial index to normal levels, to restore variability parameters, clinical condition of the patient, and facilitates the improvement of diabetic neuropathy. Conclusion . Usage of trimetazidine is practically worthy, making it to improve prognosis in coronary heart disease comorbid with DM2.
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Кочеткова et al. (2018) conducted an RCT in Stable angina with or without type 2 diabetes (n=110). Trimetazidine vs. Standard therapy without trimetazidine was evaluated on Heart rate variability parameters (Stress Index, LF/HF ratio, Myocardial Index) (p=<0.05). Trimetazidine 80 mg daily added to standard therapy significantly improved heart rate variability parameters (p<0.05) and normalized the myocardial index in patients with stable angina and type 2 diabetes.
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