Key result
Saponin administration significantly reduced serum creatine kinase levels (p<0.001) and improved histopathological changes such as lymphocyte infiltration and hyaline degeneration in cardiac tissue.
Why the study?
Cardiac abnormalities and dysfunction are major complications of cyclophosphamide treatment, necessitating effective therapies to decrease drug-induced cardiac damage.
Does saponin prevent cardiac injury induced by cyclophosphamide in male mice?
Does saponin prevent cardiac injury induced by cyclophosphamide in male mice?
p-value: p=<0.001
Saponin administration protects against cyclophosphamide-induced cardiac damage in mice by reducing myocardial injury markers and improving morphological changes.
Saponin protected against CP-induced cardiac injury in mice; leaves open translation to clinical cardioprotection.
Background and Aim: Cyclophosphamide is one of the chemotherapy drugs that has destructive effects on body tissues such as heart, liver, kidney, brain and reproductive system in human and animals. Cardiac abnormalities and dysfunction are the most important complications after cyclophosphamide (CP) treatment. Thus, investigation and development of effective treatment to decrease cardiac damage induced by cyclophosphamide are necessary. This study examined the effect of treatment with saponin (SP) on cardiac injury induced by cyclophosphamide. Materials and Methods: 24 adult male mice (weighing 30- 40 g) were randomly divided into four groups (N= 6): control, CP (15 mg/kg/week. IP), SP (5 mg/kg/day, IP) and SP + CP group. After treatment, blood samples were collected for the determination of biochemical parameters, and cardiac samples were taken for histological studies. Results: CP significantly increased myocardial injury markers (Creatine kinase, CK-MB and Lactate dehydrogenase, LDH). Histopathological findings of the CP group confirmed the lymphocyte infiltration and hyaline degeneration in the cardiac samples. Treatment with saponin boosted cardiac function and improved the morphological changes. Conclusion: It seems that saponin administration could protect against the cardiac damage induced by CP therapy.
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Golmohammadi et al. (2024) studied Cyclophosphamide-induced cardiac injury (n=24). Saponin vs. Cyclophosphamide alone was evaluated on Serum creatine kinase (CK) level and histopathological changes (p=<0.001). Saponin administration significantly reduced serum creatine kinase levels (p<0.001) and improved histopathological changes such as lymphocyte infiltration and hyaline degeneration in cardiac tissue.
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