In a rat sarcoma model, Gallium-67 showed the highest tumor uptake and most favorable tumor-to-blood ratio among tested radiopharmaceuticals.
May inform radiotracer selection in preclinical oncology; leaves open human translation for tumor imaging.
Using the transplantable Yoshida sarcoma in the rat, radiation activity concentrations were determined in tumor, blood, and muscle at various times for / sup 67/Ga-citrate, /sup 99m/Tc-pertechnetate, /sup 75/Seselenite, /sup 203/HgCl/ sub 2/, /sup 197/Hg-H-albumin, /sup 197/Hg-BMHP, /sup 20 3/Hg-chlormerodrin, and / sup 131/I-H-albumin. Gallium-67 exhibited the highest tumor uptake and the most favorable tumor/blood ratio. For some radiopharmaceuticals the extent of tumor uptake correlated with their biologic half life in the blood. There is some evidence that the model might be comparable with the human. (auth)
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Emrich et al. (1972) studied this question.
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