From previous studies on serotonin it seemed possible that it might play a major rôle in determining the rhythm of the bowel in man. This hypothesis was tested, with negative results, by observing the effect of giving bananas, a rich natural source of serotonin, to normal subjects and by measuring the excretion of 5-hydroxyindolacetic acid in patients with diarrhoea.
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Connell et al. (1960) studied this question.
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