Key result
This review outlines methodologies for measuring muscle blood flow and characterizes the dynamic response of muscle blood-flow control mechanisms during exercise onset in humans.
The application of systems-control principles provides novel insights into the non-steady-state adaptation of muscle blood flow at the onset of exercise.
Should not alter clinical exercise protocols; leaves open systems-control models for future muscle perfusion research.
Common approaches to understanding control of muscle blood flow in exercise focus on the contributions of various putative vasoregulatory mechanisms to the magnitude of the steady-state response. The application of systems-control principles offers a unique approach to characterizing and quantifying the non-steady-state adaptation of muscle blood flow with exercise onset. Information gained from this approach provides novel insight into the nature of control mechanisms governing physiological responses to exercise. This review is intended to provide the reader with an understanding of 1) exercise models, methodology for measuring muscle blood flow, and analysis approaches for quantifying muscle blood-flow dynamics; 2) what is currently known about the dynamic response of muscle blood-flow control mechanisms in humans; and 3) the similarities and differences in exercising muscle blood-flow control in the upper versus the lower limbs in humans.
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Tschakovsky et al. (2006) conducted a review in Muscle blood-flow dynamics. Muscle blood-flow dynamics at exercise onset was evaluated. This review outlines methodologies for measuring muscle blood flow and characterizes the dynamic response of muscle blood-flow control mechanisms during exercise onset in humans.
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