Key result
This state-of-the-art review summarizes the transcriptional and emerging post-transcriptional mechanisms involved in the formation and differentiation of the embryonic epicardium.
Why the study?
To provide a state-of-the-art review of the transcriptional and emerging post-transcriptional mechanisms driving the formation and differentiation of the embryonic epicardium.
This review summarizes current knowledge on the transcriptional and post-transcriptional mechanisms driving the formation and differentiation of the embryonic epicardium.
The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium surface. Subsequently, it invades the subepicardial space and thereafter the embryonic myocardium by means of epithelial-mesenchymal transition. Within the myocardium, epicardial-derived cells present multilineage potential, later differentiating into smooth muscle cells and contributing both to coronary vasculature and cardiac fibroblasts in the mature heart. Over the last decades, we have progressively increased our understanding of those cellular and molecular mechanisms driving proepicardial/embryonic epicardium formation. This study provides a state-of-the-art review of the transcriptional and emerging post-transcriptional mechanisms involved in the formation and differentiation of the embryonic epicardium.
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Carmona et al. (2023) conducted a review in Embryonic epicardium formation. This state-of-the-art review summarizes the transcriptional and emerging post-transcriptional mechanisms involved in the formation and differentiation of the embryonic epicardium.
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