Key result
Therapeutic anticoagulation with apixaban failed to prevent transcatheter heart valve thrombosis in a patient with polycythemia vera and paroxysmal atrial fibrillation.
Why the study?
The incidence of transcatheter heart valve thrombosis in patients with atrial fibrillation and on adequate anticoagulation is not well reported.
Highlights a case of transcatheter heart valve thrombosis occurring despite therapeutic anticoagulation with apixaban in a patient with polycythemia vera.
Case signals caution with apixaban for valve thrombosis prevention in polycythemia vera; leaves open optimal antithrombotic strategies.
We present a case of transcatheter heart valve thrombosis in a 76-year-old man with paroxysmal atrial fibrillation on therapeutic anticoagulation with apixaban and polycythemia vera. The incidence of transcatheter heart valve thrombosis in patients with atrial fibrillation and on adequate anticoagulation is not well reported. (Level of Difficulty: Intermediate.)
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Mahalwar et al. (2021) studied this question. Therapeutic anticoagulation with apixaban failed to prevent transcatheter heart valve thrombosis in a patient with polycythemia vera and paroxysmal atrial fibrillation.
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