Why the study?
Does aspirin disposition differ between immature and adult dogs?
Population
12 dogs, comprising 4 immature (12-16-weeks-old) and 8 adult (1-2-years-old) dogs
Comparison
Single dose of aspirin at 17.5 mg/kg body weight… vs Comparison between immature and adult dogs
Design
Preclinical
Follow-up
24 hours following each dose
Authors
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May necessitate higher aspirin doses in immature dogs for therapeutic levels; hypothesis-generating for age-specific veterinary pharmacokinetics.
Does aspirin disposition differ between immature and adult dogs?
Aspirin disposition differs significantly between immature and adult dogs, indicating that standard adult dosing regimens may be ineffective in maintaining therapeutic plasma concentrations in immature dogs.
Waters et al. (1993) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: