Key result
High cardiorespiratory fitness was associated with a significantly lower risk of all-cause mortality (HR 0.35) compared to low fitness in men with musculoskeletal conditions.
Why the study?
The study was conducted to investigate the association between cardiorespiratory fitness and the risk of cardiovascular disease, cancer, and all-cause mortality in men with musculoskeletal conditions.
Does higher cardiorespiratory fitness reduce the risk of all-cause, cardiovascular, and cancer mortality in men with musculoskeletal conditions?
Cohort (n=12,728)
No
Does higher cardiorespiratory fitness reduce the risk of all-cause, cardiovascular, and cancer mortality in men with musculoskeletal conditions?
Hazard Ratio: 0.35 (95% CI 0.22–0.53)
p-value: p=<0.01
Higher cardiorespiratory fitness is strongly associated with reduced all-cause, cardiovascular, and cancer mortality in men with musculoskeletal conditions.
May aid prognostic assessment in men with musculoskeletal conditions; hypothesis-generating and requires prospective trials.
BACKGROUND: To investigate the association between cardiorespiratory fitness and risk of cardiovascular disease, cancer, and all-cause mortality in men with musculoskeletal conditions. METHODS: Participants were 12,728 men (mean age 47.0 [9.3] y) with a history of musculoskeletal conditions (including joint pain, low back pain, stiff joints, arthritis, osteoporosis, or gout) and were followed for all-cause mortality to December 31, 2003. Fitness was quantified by maximal treadmill exercise test and was categorized for analysis as low, moderate, and high performance. Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals. RESULTS: Overall, the multivariable-adjusted hazard ratios and 95% confidence intervals for mortality across incremental fitness categories were 1.00 (reference), 0.45 (0.30-0.68) and 0.35 (0.22-0.53), linear trend P < .01 for all-cause, 0.50 (0.23-1.10) and 0.29 (0.12-0.71), linear trend P = .02 for cardiovascular disease, and 0.38 (0.20-0.74) and 0.40 (0.20-0.80), linear trend P = .01 for cancer mortality. CONCLUSION: Among men with musculoskeletal conditions, higher fitness is associated with lower risk of death by cardiovascular disease, cancer, or any cause, independent of other risk factors.
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Lemes et al. (2019) conducted a cohort in Musculoskeletal conditions (n=12,728). High cardiorespiratory fitness vs. Low cardiorespiratory fitness was evaluated on All-cause mortality (HR 0.35, 95% CI 0.22-0.53, p=<0.01). High cardiorespiratory fitness was associated with a significantly lower risk of all-cause mortality (HR 0.35) compared to low fitness in men with musculoskeletal conditions.
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