Key result
Treatment with IVIG, steroids, and aspirin normalized inflammatory markers in an 11-year-old with MIS-C, but coronary artery aneurysms and skin rash remained unresolved at 6 months.
Why the study?
Long-term follow-up of coronary artery aneurysms in patients with multisystemic inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is needed to understand long-term outcomes.
Case Report (n=1)
No
A small percentage of children with MIS-C can develop persistent coronary artery aneurysms requiring long-term follow-up, even after resolution of acute inflammation.
Persistent aneurysms in MIS-C may warrant extended surveillance; leaves open the natural history and optimal follow-up duration.
MIS-C, a well-known association with SARS-CoV-2 infection, has been a topic of significant interest. It presents with Kawasaki-like illness along with coronary artery dilation or aneurysms. In this report, we describe a particularly intriguing case of an adolescent with MIS-C presenting with coronary artery aneurysms persisting at the end of a 6-month follow-up, underscoring the importance of this condition. An 11-years-old adolescent female presented with fever, livedoid vasculitis rash over lower limbs, abdominal pain and breathlessness. Diagnosis of MIS-C was established based on the clinical findings, elevated inflammatory markers and positive SARS-CoV-2 IgG antibodies. Echocardiogram evidenced myocardial dysfunction with moderate pericardial effusion and coronary aneurysm. She was treated with intravenous immunoglobulins, steroids and aspirin. Serial follow-up until 6 months showed persisting skin changes and coronary aneurysms with normalized inflammatory markers. MIS-C and its related long-term outcome have been well recognized; however, longer follow-up is not just essential, but urgent in understanding this known yet novel condition.
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Govardhan et al. (2025) conducted a case report in Multisystemic inflammatory syndrome in children (MIS-C) with coronary artery aneurysms (n=1). Intravenous immunoglobulins, steroids, and aspirin was evaluated on Coronary artery aneurysm resolution at 6 months. Treatment with IVIG, steroids, and aspirin normalized inflammatory markers in an 11-year-old with MIS-C, but coronary artery aneurysms and skin rash remained unresolved at 6 months.
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