Answers are grounded in this paper and cite their sources.
The authors describe a light and laser scanning microscopy study of hydroxyapatite-coated titanium implants retrieved from humans. A histochemical technique, using von Kossa and basic fuchsin, allowed clear differentiation between mineralized bone and unmineralized bone matrix. The bone-hydroxyapatite (HA) interface presented variable features: in some areas the mineralized bone was directly apposed to the HA surface, while in others an unmineralized red-stained material, probably osteoid, was interposed. Laser scanning microscopy confirmed these findings showing a thin layer of fluorescent material at the interface.
No takes yet. Share an insight, caveat, or question.
Piattelli et al. (1994) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: