Key result
Familial Carney complex with PRKAR1A variant drives aggressive recurrent cardiac myxomas and sudden death.
Case Report (n=1)
Familial Carney complex-associated cardiac myxomas can exhibit an aggressive, recurrent, and fatal phenotype, underscoring the need for lifelong surveillance and timely consideration of advanced therapies like transplantation.
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May warrant intensified surveillance in Carney complex; extends phenotypic spectrum but leaves open optimal screening and management.
A et al. (2026) conducted a case report in Familial Carney complex and recurrent cardiac myxomas (n=1). PRKAR1A-Related Carney Complex was evaluated. A 42-year-old woman with familial Carney complex and a pathogenic PRKAR1A variant experienced multiple aggressive recurrences of cardiac myxomas, ultimately leading to sudden death.
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