Key result
Partial orchiectomy and mass excision effectively resolve rare testicular and scrotal Carney complex lesions.
Why the study?
Carney complex rarely involves scrotal soft tissues, prompting this report to highlight urologic manifestations and outline evaluation, treatment, and surveillance strategies.
Case Report (n=1)
This case highlights the rare urologic manifestations of Carney complex, emphasizing the need for multidisciplinary surveillance involving urology due to risks of paratesticular myxomas, LCCSCTs, and subsequent infertility.
Supports individualized surgical management of symptomatic urologic tumors in Carney complex; extends sparse case literature but leaves optimal surveillance open.
Carney complex (CNC) is a rare tumor syndrome caused by mutations in the PRKAR1A gene, characterized by endocrine tumors, cardiac and cutaneous myxomas, pigmented lesions, and testicular tumors. One to two thirds of affected males develop large cell calcifying Sertoli cell tumors (LCCSCTs), with rare involvement of scrotal soft tissues. We present a case of CNC in an adolescent male with bilateral LCCSCTs and a very large scrotal myxoma, resulting in azoospermia and pain requiring surgical management. This report highlights the urologic manifestations of CNC and outlines appropriate evaluation, treatment, and surveillance strategies relevant to pediatric and adolescent urologic practice.
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Walter et al. (2026) conducted a case report in Carney complex (n=1). Surgical excision was evaluated. Surgical excision and partial orchiectomy successfully managed a rare urologic presentation of Carney complex involving bilateral large cell calcifying Sertoli cell tumors and a large scrotal myxoma.
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