Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.
Population
101 subjects, including 51 affected members, from 11 North American kindreds with Carney complex
Design
Other
Authors
Discussion
Loading...
Member takes
Implication
Maps Carney complex to 2p16; leaves open gene identification before any clinical application.
Structured PICO
P
Population
101 subjects, including 51 affected members, from 11 North American kindreds with Carney complex
O
Outcome
Genetic linkage to chromosome 2p16surrogate
The genetic defect responsible for Carney complex maps to the short arm of chromosome 2 (2p16), providing a locus for further investigation of this familial multiple neoplasia syndrome.
Cite This Study
Stratakis et al. (1996) studied this question.