It is significant that the rule is that all sorts of epileptic and epileptiform convulsions begin in small muscles, or in muscles whose ordinary movements require little energy for the displacements they have to effect.I have advanced the hypothesis that small muscles are represented in the cerebrum by small cells, or rather that movements of parts which require little energy for the displacements they have to effect are represented by small cells.As the researches of Bevan Lewis show, this is not altogether an hypothesis in so far as "centres" in Ferrier's region are concerned; "centres", chiefly representing" small movements", are those which have fewest large cells.This matter has wide bearings.
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J. H. Jackson (1879) studied this question.