The fifth [2.2]cyclophane to be isolated—after o,o-, m,m-, p,p-, and m,p-cyclophane—is the o,m isomer 1. Only the o,p compound is absent in this series of strained arenes. The barrier for the transformation of syn-1 to anti-1 (see below) presumably lies between 20 and 24 kcal mol−1.
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Bodwell et al. (1989) studied this question.
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