Stereocontrolled Solid‐Phase Synthesis of a 90‐Membered Library of Indoline‐Alkaloid‐like Polycycles from an Enantioenriched Aminoindoline Scaffold

A library of tricyclic derivatives, similar to indoline alkaloids, has been generated by using a stereocontrolled, conjugate hetero-Michael approach in both the solution and the solid phase (see scheme; P=protecting group, R=functional group). The mild reaction conditions that lead to the tricyclic derivatives, which contain β-amino acid functionalities, are highly attractive.