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A novel, simple and highly efficient method for the synthesis of 3‐(trifluoromethyl)‐indolin‐2‐one derivatives has been developed. The protocol uses readily available N ‐alkyl‐ N ‐phenylacrylamides as the starting materials, inexpensive and easily stored Langlois reagent (sodium trifluoromethanesulfinate) as the trifluoromethyl source, and iodobenzene diacetate [PhI(OAc) 2 ] as the oxidant. The procedure involves a metal‐free domino trifluoromethylation and arylation of alkenes. The methods did not need mediation of any transition metal which avoided contaminations of toxic metals in the products. magnified image
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Shi et al. (2014) studied this question.
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