Key result
Adrenalectomy for aldosterone-producing adenoma resulted in 100% cure of hypokalaemia and 48.5% cure of hypertension over a median 5-year follow-up.
Why the study?
The study was conducted to evaluate surgical outcomes of aldosterone-producing adenoma over a 6-year period and to derive a new scoring system to predict hypertension cure after surgery.
Does unilateral adrenalectomy improve hypertension and hypokalaemia in patients with aldosterone-producing adenoma?
Observational (n=104)
Yes
Does unilateral adrenalectomy improve hypertension and hypokalaemia in patients with aldosterone-producing adenoma?
Unilateral adrenalectomy is highly effective for aldosterone-producing adenomas, curing hypokalaemia in all patients and hypertension in nearly half, with better outcomes in females with shorter hypertension duration and fewer baseline medications.
Adrenalectomy may aid hypokalaemia correction; leaves open hypertension remission durability for randomized confirmation.
Objective To evaluate surgical outcomes of patients with aldosterone‐producing adenoma (APA) over a 6‐year period from 2009 to 2014 in Hong Kong, and to derive a new scoring system to predict cure of hypertension after surgery. Methodology This was a retrospective multi‐centre study evaluating 104 APA patients from five major hospitals in Hong Kong. These patients were retrieved using database from Surgical Outcomes Monitoring and Improvement Programme (SOMIP). Their clinical characteristics and surgical outcomes were evaluated. Results Over a median follow‐up period of 5 years, APA patients who had undergone adrenalectomy had an average decrease in systolic and diastolic blood pressure of 16.9 and 4.8 mm Hg respectively. Cure of hypokalaemia, cure of hypertension and improvement in hypertension occurred in 100%, 48.5% and 40% respectively. When a patient had two of the following three parameters, namely, female sex, duration of hypertension ≤5 years and number of anti‐hypertensives ≤2, the sensitivity and specificity in achieving cure in hypertension was 79.6% and 70.6%, respectively. Surgical complications were uncommon. Conclusions Adrenalectomy resulted in resolution of hypokalaemia for all and cure of hypertension in half of the patients with APA. It was safe and effective in curing hyperaldosteronism.
No takes yet. Share an insight, caveat, or question.
Leung et al. (2021) conducted an observational in Aldosterone-producing adenoma (n=104). Adrenalectomy was evaluated on Cure of hypertension. Adrenalectomy for aldosterone-producing adenoma resulted in 100% cure of hypokalaemia and 48.5% cure of hypertension over a median 5-year follow-up.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: