Key result
Chronic angiotensin II infusion in rabbits increased the depressor response to ganglion blockade compared to vehicle (-34 vs -22 mm Hg), suggesting increased peripheral sympathetic vasoconstriction.
Absolute Event Rate: -34% vs -22%
In a rabbit model of Ang II-induced hypertension, renal sympathetic nerves do not contribute to the hypertension, but the sympathetic nervous system exerts increased vasoconstriction in the peripheral vasculature.
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Peripheral sympathetic vasoconstriction may contribute in this model; leaves open translation to human hypertension therapies.
Burke et al. (2008) studied Angiotensin II-induced hypertension. Angiotensin II infusion vs. Vehicle was evaluated on Fall in mean arterial pressure (MAP) in response to ganglion blockade after 5 weeks. Chronic angiotensin II infusion in rabbits increased the depressor response to ganglion blockade compared to vehicle (-34 vs -22 mm Hg), suggesting increased peripheral sympathetic vasoconstriction.
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