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The application of combination catalysis in enantioselective trifluoromethylation reactions is illustrated. Four ground‐breaking studies have described the efficient catalytic enantioselective nucleophilic trifluoromethylation of ketones and azomethine imines in the presence of the combination of a Cinchona alkaloid‐derived ammonium salt and different nucleophilic initiators, whereas the highly enantioselective electrophilic and radical trifluoromethylation of aldehydes could be achieved via the combination of chiral organocatalysts and metal salts.
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Zheng et al. (2010) studied this question.
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