The Genetic Aspects of Cardiovascular Diseases

Article1 September 1958THE GENETIC ASPECTS OF CARDIOVASCULAR DISEASESVICTOR A. MCKUSICK, M.D.VICTOR A. MCKUSICK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-556 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is a clinical impression of long standing that heredity plays some role in the pathogenesis of all four major types of cardiovascular disease: atherosclerosis (including coronary artery disease), hypertension, susceptibility to rheumatic fever (and therefore to rheumatic heart disease), and congenital malformations of the cardiovascular system.These are diseases of multifactorial causation. To point to a genetic factor in coronary artery disease does not deny the possible importance of diet, stress, cigarette smoking, etc. To point to a genetic factor in susceptibility to rheumatic fever does not deny the paramount importance of the streptococcus. If one demonstrates a hereditary...Bibliography1. McKusick VA: The cardiovascular aspects of Marfan's syndrome, a heritable disorder of connective tissue, Circulation 2: 321, 1955. CrossrefGoogle Scholar2. McKusick VA: Heritable Disorders of Connective Tissue, 1956, The C. V. Mosby Co., St. Louis. Google Scholar3. MattisonGuff WELE: Fusiform aneurysm of the ascending aorta associated with medionecrosis, Bull. Johns Hopkins Hosp. 98: 309, 1956. MedlineGoogle Scholar4. BahnsonNelson HTAR: Cystic medial necrosis as a cause of localized aortic aneurysms amenable to surgical treatment, Ann. Surg. 144: 519, 1956. CrossrefMedlineGoogle Scholar5. Martin R: Lehrbuch der Anthropologie, 1928, Gustav Fischer, Jena. Google Scholar6. Bauer J: Innere Sekretion, ihre Physiologie, Pathologie und Klinik, 1927, Julius Springer, Berlin, p. 361. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: VICTOR A. MCKUSICK, M.D.Affiliations: Baltimore, Maryland*From the Symposium on Genetics, presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 30, 1958.Requests for reprints should be addressed to Victor A. McKusick, M.D., Associate Professor of Medicine, The Johns Hopkins University School of Medicine, Baltimore 5, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCongenital abdominal aortic aneurysms in the young. Case report and review of the literatureMultiple aortic aneurysms (thoracic and abdominal) in twins with Marfan's syndrome: Fatal rupture during pregnancyUllrich-Turner syndrome associated with cystic medial necrosis of the aorta and great vesselsThe electrocardiogram in Marfan's syndromeAn Electrocardiographic Pattern Associated with Mitral Valve Deformity in Marfan's SyndromeHeredity and Heart DiseaseINJURY BY THE DOMESTIC LAWN MOWERMARFAN'S SYNDROME COMPLICATED BY DISSECTING ANEURYSM OF THE AORTA 1 September 1958Volume 49, Issue 3 Page: 556-567 Keywords Aorta Atherosclerosis Cardiovascular diseases Genetic diseases Hypertension Marfan syndrome Pathogenesis Rheumatic fever Stable coronary artery disease Streptococcus ePublished: 1 December 2008 Issue Published: 1 September 1958 PDF downloadLoading ...