The role of the co-receptors 2B4/CD48 in allergic eosinophilic airway inflammation

Eosinophils have a pivotal role in the pathogenesis of allergic airway disorders. They express a variety of receptors involved in their activation. Recently, the role of the CD2 Ig superfamily of receptors in eosinophilic inflammation, especially 2B4 and CD48, has been explored in allergic rhinitis and asthma. In recent years, there has been increasing evidence suggesting that these two molecules have an important role in allergic airway disorders. In this article, the most recently acquired data on the role of CD48 and 2B4 in allergic airway disorders are reviewed.