Why the study?
Does chlorisondamine reduce choline acetyltransferase activity in postganglionic parasympathetic nerves of parotid glands in adult rats?
Does chlorisondamine reduce choline acetyltransferase activity in postganglionic parasympathetic nerves of parotid glands in adult rats?
Pharmacological decentralization with chlorisondamine reduces choline acetyltransferase activity and induces supersensitivity in the parotid glands of rats.
Rat parotid effects should not alter clinical practice; leaves open human parasympathetic decentralization relevance.
The ganglion blocking drug chlorisondamine given frequently and in gradually increasing doses over a period of time to adult rats causes the activity of choline acetyltransferase to fall in the postganglionic parasympathetic nerves of parotid glands. Such a "pharmacologically" decentralized gland was also found to have lost weight and to have developed a supersensitivity to chemical stimuli. All these phenomena are thought to be consequences of loss or reduction of secretory impulses from the central nervous system due to impaired ganglionic transmission.
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Ekström et al. (1978) studied this question.
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