Key result
This state-of-the-art overview describes the anatomical and functional relationships between the mitral valve and left ventricle, highlighting mechanisms and therapeutic strategies for functional mitral regurgitation.
Why the study?
Impaired coordination between the mitral valve and the left ventricle can lead to valvular dysfunction with serious clinical consequences, requiring comprehension of these mechanisms to guide appropriate therapeutic solutions.
This state-of-the-art overview summarizes the anatomical and functional interactions between the left ventricle and mitral valve, highlighting the pathophysiology of functional mitral regurgitation and the distinction between proportionate and disproportionate FMR to guide therapeutic strategies.
Enhances clinician grasp of FMR mechanisms; leaves open optimal therapy selection for prospective trials.
In this overview, we described the mitral valve anatomy, focusing on its anatomical and functional relationships with the left ventricle (LV), and how an impaired coordination between the two can lead to valvular dysfunction with serious clinical consequences. In the 1st part of this overview, we sought to describe the anatomy of the mitral valve apparatus. In the 2nd part, we sought to analyze the interactions of the LV with the mitral valve, the possible etiologies that cause mitral regurgitation (MR), and therapeutic strategies that can be utilized nowadays in the effort to reinstate normal valvular function. The comprehension of these mechanisms makes it possible to implement appropriate therapeutic solutions in order to alleviate the burden of mitral valve disease.
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Donal et al. (2021) conducted an editorial in Functional mitral regurgitation. This state-of-the-art overview describes the anatomical and functional relationships between the mitral valve and left ventricle, highlighting mechanisms and therapeutic strategies for functional mitral regurgitation.
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